By Karolin K. Kroening
This ebook describes nerve brokers and vesicants, their decomposition and their degradation items' chemistry in addition to their toxicity together with an inventory of detection innovations of nerve brokers and their degradation items. This e-book will current their historical past, toxicity, comparability among assorted pattern coaching equipment, separation ideas, and detection tools all jointly in a quick, effortless to learn e-book, tied jointly by means of a unmarried crew doing the writing and the enhancing to guarantee tender transition from bankruptcy to bankruptcy, with enough Tables and literature references for the reader who seems to extra detail.The textual content will illustrate the pluses and minuses of many of the innovations with enough references for the reader to procure vast aspect.
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Extra resources for Analysis of Chemical Warfare Degradation Products
66] National Toxicology Program, (1986) Toxicology and Carcinogenesis Studies of Methyl Methacrylate (CAS No. 80-62-6) in F344/N Rats and B6C3F1 Mice (Inhalation Studies), National Toxicology Program, Research Triangle Park, NC. J. et al. (1964) Toxicol. Appl. , 6, 29–36. W. (1991) Mutat. , 257, 229–306. M. (1989) Mutat. , 222, 191–203. L. et al. (1986) Environ. , 8, 4. , Sugiyama, A. et al. (1995) Mutat. , 343, 157–183. , Autian, J. (1979) Toxicol. Appl. , 50, 451–458. -Z. (1986) Toxicol. , 31, 80.
The use of scavengers, typically proteins or antibodies, follows a detoxification pathway in which the nerve agent is bound or degraded prior to penetration of the target site (cholinesterase enzyme). Enzymes that bind nerve agents are typically referred to as stoichiometric scavengers, while enzymes that hydrolyze nerve agents are called catalytic scavengers . A variety of cholinesterases have been utilized as scavengers against nerve agent exposure . Reversible AChE inhibitors protect the normal function of AChE through a modification of the enzyme making it resistant to nerve agent exposure.
Nonetheless, median lethal dose (LD50 ) or median lethal concentration (LC50 ) values are given for dimethylamine, diethyl dimethylphosphoramidate and triethyl phosphate. Lowest lethal dose (LDLO ) or lowest lethal concentration (LCLO ) values are only given for triethyl phosphate. Dimethylamine can be absorbed orally or by inhalation and is considered to be acutely toxic according to studies. In humans, severe burns can occur in the eye and on the skin with strong irritations to the olfactory system, similar to that of ammonia.
Analysis of Chemical Warfare Degradation Products by Karolin K. Kroening