By Dr. L. F. Agnati, O. Franzen, S. Ferré, G. Leo (auth.), Dr. R. Horowski, Prof. Y. Mizuno, Prof. C. W. Olanow, Prof. W. H. Poewe, Prof. P. Riederer, Dr. J. A. Stoessl, Prof. M. B. H. Youdim (eds.)
• attainable position of intramembrane receptor-receptor interactions in reminiscence and studying through formation of long-lived heteromeric complexes: specialise in motor studying within the basal ganglia (L.F. Agnati, O. Franzen, S. Ferré, G. Leo, R. Franco, ok. Fuxe) •Self-tolerance within the immune privileged CNS: classes from the entorhinal cortex lesion version (E. Kwidzinski, L. ok. Mutlu, A. D. Kovac, J. Bunse, J. Goldmann, J. Mahlo, O. Aktas, F. Zipp, T. Kamradt, R. Nitsch, I. Bechmann) •Progressive neurodegeneration in Drosophila: a version method (J.-A. Tschäpe, A. Bettencourt da Cruz, D. Kretzschmar) •Effect of complicated glycation endproducts on phone cycle and their relevance for Alzheimer`s ailment (G. Münch, J. Gasic-Milenkovic, T. Arendt) •What have we learnt from cDNA microarray gene expression reports concerning the position of iron in MPTP precipitated neurodegeneration and Parkinson`s disorder? (M. B. H. Youdim) •Animal types of Parkinson`s disorder in rodents brought on via pollutants: an replace (E. C. Hirsch, G. Höglinger, E. Rousselet, T. Breidert, ok. Parain, J. Feger, M. Ruberg, A. Prigent, C. Cohen-Salmon, J.-M. Launay) •General points of neurodegeneration (K. A. Jellinger) •The neuromelanin of human substantia nigra: constitution, synthesis and molecular behaviour (L. Zecca, F. A. Zucca, P. Costi, D. Tampellini, A. Gatti, M. Gerlach, P. Riederer, R. G. Fariello, S. Ito, M. Gallorini, D. Sulzer) •New techniques and instruments in imaging for the research of neurodegenerative affliction (A. J. Stoessl, C. S. Lee, R. de los angeles Fuente-Fernandez) •Arguments for using dopamine receptor agonists in scientific and preclinical Parkinson`s affliction (M. Gerlach, okay. Double, H. Reichmann, P. Riederer) •The position of acetylcholine and dopamine in dementia and psychosis in Parkinson`s sickness (J. L. W. Bosboom, D. Stoffers, E. Ch. Wolters) •Growth/differentiation factor-15 (GDF-15), a singular member of the TGF-ß superfamily, promotes survival of lesioned mesencephalic dopaminergic neurons in vitro and in vivo and is precipitated in neurons following cortical lesioning (J. Strelau, A. Schober, A. Sullivan, L. Schilling, okay. Unsicker) •Gene remedy for Parkinson`s disorder (H. Mochizuki, Y. Mizuno) •Stereotaxic intrastriatal implantation of human retinal pigment epithelial (hRPE) cells hooked up to gelatin microcarriers: a possible new mobile treatment for Parkinson`s disorder (R. L. Watts, C. D. Raiser, N. P. Stover, M. L. Cornfeldt, A. W. Schweikert, R. C. Allen, T. Subramaniam, D. Doudet, C. R. Honey, R. A. E. Bakay)
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Additional info for Advances in Research on Neurodegeneration: Volume 10
Interestingly, induction of T cell tolerance seems to occur within the CNS. MBP-specific T cells isolated from the CNS (but not T cells specific for nonCNS antigens) are unresponsive to antigenic stimulation in vitro. Further- 32 E. K widzinski et al. , 2000). , 2001). , 2002). , 1996). Dendritic cells (DC) can induce a primary immune response by activating naive T cells. Strikingly, DC can only be detected in the leptomeninges and the choroid plexus of the ventricular system (McMenamin, 1999), both of which are not immune privileged.
J Neurosci 15;20(14): 5283-5291 Harling Berg CJ, Park TJ, Knopf PM (1999) Role of the cervical lymphatics in the Th2type hierarchy of CNS immune regulation. J NeuroimmunoI101(2): 111-127 Hart DN, Fabre JW (1981) Demonstration and characterization of la-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain. J Exp Med 154(2): 347-361 Hauben E, Agranov E, Gothilf A, Nevo U, Cohen A, Smirnov I, Steinman L, Schwartz M (2001) Posttraumatic therapeutic vaccination with modified myelin self-antigen prevents complete paralysis while avoiding autoimmune disease.
In contrast to a previous study using ECL in rats (Fagan and Gage, 1994), we could show that antigen-presenting microglia do express MHC-II molecules (Fig. 4f-g) and T cells do invade the hippocampus (Fig. , 2001). Yet destructive autoimmunity does not occur, even in highly susceptible strains including MBP-specific T cell receptor transgenic mice (unpublished observation). These findings again highlight that antigens after brain lesion are not ignored by the immune system and therefore mechanisms of immune tolerance must act to prevent development of destructive autoimmunity.
Advances in Research on Neurodegeneration: Volume 10 by Dr. L. F. Agnati, O. Franzen, S. Ferré, G. Leo (auth.), Dr. R. Horowski, Prof. Y. Mizuno, Prof. C. W. Olanow, Prof. W. H. Poewe, Prof. P. Riederer, Dr. J. A. Stoessl, Prof. M. B. H. Youdim (eds.)