By John G. Bartlett MD
Designed to supply easy accessibility to criteria of take care of infectious affliction through concentrating on choice, right doses, expenditures, and uncomfortable side effects of antimicrobial brokers, the 2005-2006 notebook of Infectious sickness Therapy attracts broadly from ideas made via the facilities for ailment keep watch over and Prevention, the clinical Letter on medications and Therapeutics, and from reliable statements of revered clinical societies. Tabular fabric has been up-to-date to incorporate all newly authorized antibiotics, in addition to new thoughts for management.
This version contains topical concerns similar to MRSA (USA three hundred strain), Avian influenza, Acinetobacter Hepatitis B virus (HBV), hepatitis C virus (HCV), and bioterrorism. It additionally includes the hot guidance for pyogenic meningitis, diabetic foot infections, healthcare linked pneumonia, surgical prophylaxis, fungal infections, bacteruria, and administration of infections linked to foreign travel.
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Additional resources for 2005-2006 Pocket Book of Infectious Disease Therapy
53 Quinupristin/dal fopristin Hepati c metab olism 1. 5 1. 5 — 7. 5 mg /k g q8 12 h Us ua l Usual Usual Ribavirin Hepati c 0. 2 g/d — Us ua l Not recomm ended Not recomm ended Rifampin Hepati c E a rl y 25 L a t e 2 25 600 mg/ d 60 0 mg /d Us ua l Usual Usual or half dose Rifapentine Hepati c 1 61 9 h — 600 mg 2×/ wk — Us ua l Usual Usual Rimantadine Hepati c 2 43 0 4 86 0 100 mg bid — Us ua l Usual 100 mg/d Spectinomycin Renal 13 ? 5 g q1224h (1/3 dose) Sulfisoxazole Renal 37 61 2 1-2 g q6h — Us ua l 1 g q812h 1 g q1224h Telithromycin Hepati c 9.
B. Maintenance dose: Cockcroft-Gault equation. 3. MONITORING: Measure peak levels at 1 hr after start of 20- to 30-min infusion. Goal with q8h dosing is 5-10 μg/mL for gentamicin and tobramycin or 20-40 μg/mL for amikacin; peak levels when using low doses of gentamicin or tobramycin for synergy vs staph, strep or enterococcus is 3 μg/mL. Monitor for nephrotoxicity with serum creatinine qd or qod. Monitor for ototoxicity when feasible in patients treated >3 days with periodic Romberg's sign and with reading an eye chart after rapid head movements.
Penicillinase-resistant penicillins: nafcillin, oxacillin, methicillin, cloxacillin, dicloxacillin. 4. Tetracycline: Tetracycline, doxycycline, minocycline. 5. Cephalosporins and miscellaneous beta-lactams 1st generation: Cefadroxil,* cefazolin, cephalexin,* cephapirin, cephradine* 2nd generation: Cefaclor,* cefaclor ER, cefamandole, ceforanide, cefotetan, cefoxitin, cefuroxime,* cefprozil,* loracarbef* 3rd generation: Cefotaxime, ceftizoxime, ceftazidime, cefoperazone, ceftriaxone, moxalactam, cefixime,* cefpodoxime,* cefdinir,* cefditoren,* ceftibuten* 4th generation: Cefepime Cephamycins: Cefoxitin, cefotetan Monobactam: Aztreonam Carbapenem: Imipenem, meropenem, ertapenem Carbacephem: Loracarbef* 6.
2005-2006 Pocket Book of Infectious Disease Therapy by John G. Bartlett MD