By Christopher Schofield, Robert Hausinger, C David Garner, Martin J Bollinger, Johanna Myllyharju, Ray Trievel, Tina Muller, Pål Falnes, L Aravind, Robert Sabbatini, Christopher J Schofield, Ronald Wanders, Stefan Martens, Peter Hedden, Inger Andersson, Jan
Because the discovery of the 1st examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions within the Nineteen Sixties, a remarkably large variety of trade reactions and substrates has been printed, and large advances were accomplished in our realizing of the buildings and catalytic mechanisms. those enzymes are vital agrochemical goals and are being pursued as healing pursuits for a variety of ailments together with melanoma and anemia.
This booklet offers a important resource of data that summarizes the foremost gains of the basic crew of 2-oxoglutarate-dependent dioxygenases and comparable enzymes. Given the varied fresh advances and biomedical curiosity within the box, this booklet goals to unite the newest study for these already operating within the box in addition to to supply an advent for these newly impending the subject, and for these drawn to translating the fundamental technology into medicinal and agricultural benefits.
The e-book starts off with 4 large chapters that spotlight severe facets, together with an outline of attainable catalytic reactions, constructions and mechanisms. the subsequent seventeen chapters concentrate on rigorously chosen subject matters, every one written through major specialists within the sector. Readers will locate motives of swiftly evolving examine, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in DNA through ten-eleven-translocase oxygenases.
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Extra resources for 2-Oxoglutarate-Dependent Oxygenases
Coumarins (1,2-benzopyrones) such as scopoletin and umbelliferone are synthesized by many higher plants where they are used for defence against phytopathogens. 8G). 221 10:21:49. org | doi: 20 genases. (A) Hydroxylase and epoxidase activities of hyoscyamine hydroxylase. (B) Desacetoxyvindoline 4-hydroxylase. (C) Thebaine 6-O-demethylase. (D) Codeine O-demethylase. (E) LolO-catalysed ether bridge formation in loline alkaloid biosynthesis. (F) Mugineic acid phytosiderophore synthesis. (G) Feruloyl-CoA 6′-hydroxylase and p-coumaroyl-CoA 2′-hydroxylase in the pathways for synthesis of scopoletin and umbelliferone (yellow highlight).
210 Further information on this remarkable family of enzymes is available in Chapter 16. 3 2OG-Dependent Oxygenases in Alkaloid Synthesis Four examples are depicted to illustrate how plants use 2OG-dependent oxygenases for alkaloid biosynthesis. Scopolamine is a hallucinogenic tropane alkaloid produced by Hyoscyamus niger (henbane). The last two steps in its synthesis are catalysed by hyoscyamine 6β-hydroxylase that carries out both 10:21:49. org | doi: 18 (B) Three consecutive reactions of GA C20 oxidase that convert a methyl group to an alcohol, aldehyde and carboxylic acid; a distinct reaction catalysed by GA C20 oxidase to eliminate CO2 and form a γ-lactone; GA 2β and GA 3β oxidase activities.
A. McDonough, D. Ehrismann, N. J. Kershaw, N. Granatino and C. J. Schofield, J. Inorg. , 2006, 100, 644–669. M. A. McDonough, C. Loenarz, R. Chowdhury, I. J. Clifton and C. J. Schofield, Curr. Opin. Struct. , 2010, 20, 1–14. View Online 10:21:49. W. Aik, M. A. McDonough, A. Thalhammer, R. Chowdhury and C. J. Schofield, Curr. Opin. Struct. , 2012, 22, 1–10. D. A. Proshlyakov and R. P. Hausinger, in Iron-containing Enzymes: Versatile Catalysts of Hydroxylation Reactions in Nature, ed. D. Kumar and S.
2-Oxoglutarate-Dependent Oxygenases by Christopher Schofield, Robert Hausinger, C David Garner, Martin J Bollinger, Johanna Myllyharju, Ray Trievel, Tina Muller, Pål Falnes, L Aravind, Robert Sabbatini, Christopher J Schofield, Ronald Wanders, Stefan Martens, Peter Hedden, Inger Andersson, Jan